Here, we confirm the existence of the single S-cone center OFF midget RGC circuit in the central retina of macaque monkey both structurally and functionally, by combining single cell electrophysiology with 3D electron microscopy reconstructions of the upstream circuitry. Like the well-studied L vs. M midget RGCs, the S-OFF midget RGCs have a ...
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view more202042 · Much of the S-cone amacrine cell’s output is targeted to ipRGCs, another highly conserved neuron mediating ancient non-image-forming visual functions. Accordingly, the S-cone amacrine cell may be part of an evolutionarily ancient color vision circuit, not for hue perception, but for non-image-forming vision.
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view more2019815 · S-cone circuits of the outer retina. To confirm the existence of S-OFF midget RGCs using serial electron microscopy (EM; Fig. 1A), a first step was to reliably identify S-cones.We identified candidate S-cones by their small size and lack of long telendondria, branches forming gap junctions with neighboring cones 5.While S-cones …
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view more202044 · Serial EM reconstruction of ipRGCs and the S-cone connectome in primate retina. (A) Four representative S-cones (arrows) and their S-ON bipolar cell (blue) and OFF midget bipolar cell (purple) contacts.(B) Small bistratified RGC circuit used for verification of S-cone and S-ON bipolar cell identification.(C) 3D reconstruction of the small bistratified …
view more202046 · Much of the S-cone amacrine cell’s output is targeted to ipRGCs, another highly conserved neuron mediating ancient non-image-forming visual functions. Accordingly, the S-cone amacrine cell may be part of an evolutionarily ancient color vision circuit, not for hue perception, but for non-image-forming vision.
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