high throughput screening methods

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  Discovering New Substrates of a UDP-Glycosyltransferase with a High ...

  2024227 · This method is based on detecting the formation of UDP molecules when the glycosyl moiety of UDP-glucose dissociates from UDP during the glycosylation reaction. The ease of receiving a readout allows the use of this method to perform high-throughput screening for substrates of a plant UGT homology, UGT71G1, from Medicago truncatula.

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  High-Throughput Screening Techniques for the Selection of …

  However, all of these approaches require sensitive and reliable high-throughput screening (HTS) technologies to efficiently and rapidly identify variants with improved properties. While numerous reviews focus on modification strategies for enhancing enzyme thermostability, there is a dearth of literature reviewing HTS methods specifically aimed ...

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  Influence relevance voting: an accurate and interpretable virtual high ...

  Abstract. Given activity training data from high-throughput screening (HTS) experiments, virtual high-throughput screening (vHTS) methods aim to predict in silico the activity of untested chemicals. We present a novel method, the Influence Relevance Voter (IRV), specifically tailored for the vHTS task. The IRV is a low-parameter neural network ...

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  High-Throughput Methods in the Discovery and Study of …

  The complex interaction of cells with biomaterials (i.e., materiobiology) plays an increasingly pivotal role in the development of novel implants, biomedical devices, and tissue engineering scaffolds to treat diseases, aid in the restoration of bodily functions, construct healthy tissues, or regenerate diseased ones. However, the conventional approaches are …

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  High-throughput proteomics: a methodological mini-review

  202283 · Traditional statistics methods, such as Student’s t-test and one-way analysis of variance (ANOVA), have various biases and may be time-consuming to handle big data 78.Therefore, new high ...

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  Efficient Ternary Mn‐Based Spinel Oxide with Multiple Active …

  20221110 · Given the large numbers of possible binary and ternary metal oxide OER catalysts, high-throughput methods are necessary to accelerate the rate of discovery. Herein, Mn-based spinel oxide, Fe 10 Co 40 Mn 50 O, is identified for the first time using high-throughput methods demonstrating remarkable catalytic activity (overpotential of 310 …

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  High-content CRISPR screening | Nature Reviews Methods …

  2022210 · CRISPR screening is a high-throughput approach for identifying genes, pathways and mechanisms involved in a given phenotype or biological process. High-content read-outs of these screens, such as ...

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  High-Throughput Methods in the Discovery and Study of

  2021321 · In this review, we first introduce materiobiology and its high-throughput screening (HTS). Then we present an in-depth of the recent progress of 2D/3D HTS platforms (i.e., gradient and microarray) in the principle, preparation, screening for materiobiology, and combination with other advanced technologies.

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  Quantitative High-Throughput Screening Methods Designed …

  2022427 · In this study, we present two quantitative and high-throughput methods to assess the inhibitory capacity of bacterial biocontrol candidates against fungal phytopathogens. One method measures the inhibitory effect of bacterial culture supernatant components on the fungal growth, while the other accounts for direct interaction between …

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  High-throughput screening goes to school | Nature Methods

  2024321 · Nature Methods 4 , 523–532 ( 2007) Cite this article. High-throughput screening, traditionally the domain of big pharmaceutical companies, is now creeping into academic laboratories in the guise ...

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